SHARPIN

Across TCGA pan-cancer cohorts, SHARPIN Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SHARPIN data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher SHARPIN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHARPIN expression acts as an unfavorable survival marker.

SARC and LUAD are the cancer types where SHARPIN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.156	0.767	.001	6	view →
LUAD	OS	Median	All	0.241	0.684	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SHARPIN–SARC (OS)

Open the SARC breakdown →