SHARPIN

Across TCGA pan-cancer cohorts, SHARPIN mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SHARPIN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SHARPIN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SHARPIN is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where SHARPIN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHARPIN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.189	<.001	11	view →
CCRCC	Male	III,IV	+0.213	<.001	7	view →
PDAC	All	II,III,IV	−0.245	<.001	6	view →
COAD	All	All	−0.222	.016	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SHARPIN–HNSC

Open the HNSC breakdown →