SH3YL1

Across TCGA cell cohorts, SH3YL1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3YL1-associated genes across cancer lineages are CD1A, SLC10A2, and KRTAP5-4. Each is linked with SH3YL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3YL1-to-partner and partner-to-SH3YL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD1A grouped by SH3YL1-low versus SH3YL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3YL1→partner) and Y-score (partner→SH3YL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD1A →	+0.022	+3.347	.001	.005	3	1
SKIN	SLC10A2 →	+0.006	+6.022	<.001	.001	3	1
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
LARGE_INTESTINE	ADGRL4 →	+0.078	+3.569	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD1A by SH3YL1 expression — LARGE_INTESTINE

Explore this box plot interactively →