SH3TC2-DT

Across TCGA pan-cancer cohorts, SH3TC2-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SH3TC2-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SH3TC2-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SH3TC2-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

ACC, KIRC, and PAAD are the cancer types where SH3TC2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	II,III,IV	0.208	0.659	.001	79	view →
KIRC	DFS	Tertile	II,III,IV	0.390	0.655	<.001	78	view →
PAAD	DFS	Tertile	All	0.328	0.556	<.001	74	view →
UCS	DFS	Median	II,III,IV	0.583	0.149	.002	62	view →
KICH	OS	Tertile	All	0.815	0.962	.007	44	view →
UVM	DFS	Tertile	III,IV	0.371	0.809	.002	31	view →
LUAD	DFS	Median	IV	0.473	0.798	.005	28	view →
SKCM	OS	Median	All	0.403	0.270	<.001	22	view →
READ	OS	Tertile	II,III,IV	0.882	0.461	.005	19	view →
PCPG	OS	Tertile	All	0.909	1.000	.004	15	view →
KIRP	DFS	Median	All	0.777	0.944	.011	12	view →
LAML	DFS	Median	All	0.264	0.458	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SH3TC2-DT–ACC (OS)

Open the ACC breakdown →