SH3TC1

Across TCGA pan-cancer cohorts, SH3TC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH3TC1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SH3TC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3TC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where SH3TC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.910	0.370	.004	14	view →
PDAC	OS	Quartile	All	0.691	0.349	.002	13	view →
CCRCC	DFS	Tertile	III,IV	0.643	0.309	.006	11	view →
HNSC	OS	Tertile	III,IV	0.808	0.519	.008	10	view →
GBM	OS	Quartile	All	0.410	0.696	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH3TC1–UCEC (DFS)

Open the UCEC breakdown →