SH3TC1

Across TCGA patient cohorts, SH3TC1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,082 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH3TC1-associated genes across cancer lineages are TGFBR2, NLRC4, and SH2D3C. Each is linked with SH3TC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SH3TC1-to-partner and partner-to-SH3TC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3TC1 versus TGFBR2 in LSCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC1→partner) and Y-score (partner→SH3TC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TGFBR2 →	+0.775	+0.452	<.001	<.001	3	5
GBM	NLRC4 →	+0.512	+0.383	<.001	<.001	3	5
CCRCC	SH2D3C →	+0.786	+0.285	<.001	<.001	3	5
UCEC	OIP5 →	-1.003	-0.983	.003	.001	3	5
LSCC	CARD6 →	+0.749	+0.435	<.001	<.001	3	5
GBM	GIMAP4 →	+0.966	+0.493	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,082 associations by consensus.

SH3TC1 vs TGFBR2 — LSCC

Explore this scatter interactively →