SH3TC1

Across TCGA patient cohorts, SH3TC1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3TC1-associated genes across cancer lineages are Cyclin-E2, Annexin_VII, and c-Kit. Each is linked with SH3TC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3TC1-to-partner and partner-to-SH3TC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SH3TC1-low versus SH3TC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC1→partner) and Y-score (partner→SH3TC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.299	+2.828	<.001	.033	3	3
STAD	Annexin_VII →	-0.186	-3.169	.020	.019	3	2
STAD	c-Kit →	-0.471	-3.169	.002	.019	3	2
STAD	C-Raf →	+0.263	+3.000	<.001	.034	2	3
UCEC	STAT3_pY705 →	-0.330	-2.127	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.173	-2.060	.019	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Cyclin-E2 by SH3TC1 expression — STAD

Explore this box plot interactively →