SH3TC1

Across TCGA cell cohorts, SH3TC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,941 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3TC1-associated GO terms across cancer lineages are Protein targeting to ER, Negative regulation of response to endoplasmic reticulum stress, and Establishment of protein localization to endoplasmic reticulum. Each is linked with SH3TC1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SH3TC1-to-partner and partner-to-SH3TC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to ER grouped by SH3TC1-low versus SH3TC1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC1→partner) and Y-score (partner→SH3TC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein targeting to ER →	+0.083	+2.338	.001	.001	2	10
LARGE_INTESTINE	Negative regulation of response to endoplasmic reticulum stress →	+0.090	+1.050	<.001	<.001	3	9
URINARY_TRACT	Establishment of protein localization to endoplasmic reticulum →	+0.074	+2.303	.001	.001	1	11
OESOPHAGUS	Regulation of response to cytokine stimulus →	+0.102	+2.073	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.076	+1.984	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.108	+1.875	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,941 associations by consensus.

Protein targeting to ER by SH3TC1 expression — URINARY_TRACT

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