SH3TC1

Across TCGA cell cohorts, SH3TC1 mutation is significantly associated with the RNA expression of many other genes, with 320 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3TC1-associated genes across cancer lineages are TMEM252, C17orf98, and IQCF3. Each is linked with SH3TC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3TC1-to-partner and partner-to-SH3TC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM252 grouped by SH3TC1-low versus SH3TC1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC1→partner) and Y-score (partner→SH3TC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMEM252 →	+0.637	+4.217	<.001	.005	3	2
SOFT_TISSUE	C17orf98 →	+0.072	+3.865	<.001	.006	3	2
BREAST	IQCF3 →	+0.113	+5.781	<.001	.001	3	2
BLOOD_Lymphoma	PIP →	+0.094	+3.165	.001	.004	3	2
BLOOD_Lymphoma	B3GNT6 →	+0.458	+3.610	.002	.007	3	2
LARGE_INTESTINE	NOA1 →	+0.585	+3.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 320 associations by consensus.

TMEM252 by SH3TC1 expression — URINARY_TRACT

Explore this box plot interactively →