SH3PXD2B

Across TCGA patient cohorts, SH3PXD2B mutation is significantly associated with the RNA expression of many other genes, with 2,657 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3PXD2B-associated genes across cancer lineages are CDK11B, ZNF662, and RPL23AP82. Each is linked with SH3PXD2B in more than 3 cancer types. Because this analysis shows association rather than direction, both SH3PXD2B-to-partner and partner-to-SH3PXD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK11B grouped by SH3PXD2B-low versus SH3PXD2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2B→partner) and Y-score (partner→SH3PXD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK11B →	+0.286	+2.147	.004	<.001	3	4
UCEC	ZNF662 →	-0.523	-2.478	.004	.001	3	3
SKCM	RPL23AP82 →	+0.535	+3.350	.003	.005	3	3
UCEC	NELFB →	+0.415	+3.140	<.001	<.001	3	3
UCEC	ATAD3A →	+0.384	+3.032	.001	<.001	3	3
UCEC	FCGR3A →	+0.954	+4.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,657 associations by consensus.

CDK11B by SH3PXD2B expression — UCEC

Explore this box plot interactively →