SH3PXD2B

Across TCGA pan-cancer cohorts, SH3PXD2B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SH3PXD2B data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SH3PXD2B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SH3PXD2B expression acts as an unfavorable survival marker, although some lineages such as ESCA and COAD show a favorable association.

MESO, UVM, and BLCA are the cancer types where SH3PXD2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.257	0.501	<.001	117	view →
UVM	DFS	Median	All	0.428	0.788	<.001	101	view →
BLCA	OS	Tertile	All	0.533	0.729	<.001	93	view →
LIHC	DFS	Median	All	0.445	0.639	<.001	83	view →
OV	DFS	Median	II,III,IV	0.336	0.421	.009	52	view →
LGG	DFS	Median	All	0.660	0.819	<.001	49	view →
SKCM	OS	Median	All	0.740	0.826	<.001	33	view →
CESC	DFS	Tertile	All	0.375	0.669	.006	24	view →
LUAD	DFS	Quartile	All	0.547	0.773	.012	24	view →
KICH	DFS	Median	II,III,IV	0.719	0.958	.017	20	view →
ESCA	OS	Median	III,IV	0.701	0.444	.012	18	view →
HNSC	OS	Tertile	II,III,IV	0.284	0.603	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SH3PXD2B–MESO (OS)

Open the MESO breakdown →