SH3PXD2B

Across TCGA patient cohorts, SH3PXD2B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3PXD2B-associated genes across cancer lineages are C-Raf, Annexin-1, and ATM. Each is linked with SH3PXD2B in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3PXD2B-to-partner and partner-to-SH3PXD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SH3PXD2B-low versus SH3PXD2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2B→partner) and Y-score (partner→SH3PXD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.196	+2.815	.014	.036	3	3
UCEC	Annexin-1 →	+0.739	+3.926	<.001	<.001	3	3
UCEC	ATM →	-0.627	-3.687	<.001	.001	3	3
UCEC	MEK1 →	+0.412	+2.169	.002	.003	3	2
COAD	Caspase-7-cleavedD198 →	+1.320	+2.815	.002	.036	3	2
UCEC	EGFR_pY1068 →	-0.302	-2.662	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

C-Raf by SH3PXD2B expression — COAD

Explore this box plot interactively →