SH3PXD2B

Across TCGA cell cohorts, SH3PXD2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,320 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3PXD2B-associated GO terms across cancer lineages are Podosome assembly, ATP metabolic process, and Regulation of myoblast fusion. Each is linked with SH3PXD2B in more than 13 cancer types. Because this analysis shows association rather than direction, both SH3PXD2B-to-partner and partner-to-SH3PXD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Podosome assembly grouped by SH3PXD2B-low versus SH3PXD2B-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2B→partner) and Y-score (partner→SH3PXD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Podosome assembly →	+0.197	+1.728	<.001	<.001	3	14
LARGE_INTESTINE	ATP metabolic process →	+0.060	+1.250	.002	.001	3	11
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.100	+1.458	<.001	<.001	3	11
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.119	+1.408	<.001	.003	3	11
BLOOD_Lymphoma	Negative regulation of syncytium formation by plasma membrane fusion →	+0.119	+1.408	<.001	.003	3	10
SOFT_TISSUE	Golgi vesicle transport →	+0.050	+0.965	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,320 associations by consensus.

Podosome assembly by SH3PXD2B expression — BREAST

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