SH3PXD2B

Across TCGA cell cohorts, SH3PXD2B mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SH3PXD2B-associated genes across cancer lineages are CCL8, GPR101, and SSTR4. Each is linked with SH3PXD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3PXD2B-to-partner and partner-to-SH3PXD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL8 grouped by SH3PXD2B-low versus SH3PXD2B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2B→partner) and Y-score (partner→SH3PXD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCL8 →	+0.236	+4.095	<.001	.009	3	1
SKIN	GPR101 →	+0.015	+5.022	<.001	.002	3	1
BLOOD_Leukemia	SSTR4 →	+0.061	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR13C7 →	+0.023	+5.969	<.001	.001	3	1
BLOOD_Leukemia	ADAM7 →	+0.021	+4.922	.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CCL8 by SH3PXD2B expression — SKIN

Explore this box plot interactively →