SH3PXD2A

Across TCGA patient cohorts, SH3PXD2A mutation is significantly associated with the RNA expression of many other genes, with 4,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3PXD2A-associated genes across cancer lineages are ENO2, ACTR1A, and CHAF1A. Each is linked with SH3PXD2A in more than 3 cancer types. Because this analysis shows association rather than direction, both SH3PXD2A-to-partner and partner-to-SH3PXD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENO2 grouped by SH3PXD2A-low versus SH3PXD2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2A→partner) and Y-score (partner→SH3PXD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENO2 →	+0.532	+1.818	.002	.002	3	4
SKCM	ACTR1A →	+0.358	+2.604	.002	<.001	3	4
UCEC	CHAF1A →	+0.634	+2.099	<.001	<.001	3	3
UCEC	PRC1 →	+0.592	+2.906	<.001	<.001	3	3
SKCM	AIFM2 →	+0.513	+2.591	.006	<.001	3	3
UCEC	RNA5SP415 →	+0.286	+1.410	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,535 associations by consensus.

ENO2 by SH3PXD2A expression — UCEC

Explore this box plot interactively →