SH3PXD2A

Across TCGA patient cohorts, SH3PXD2A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3PXD2A-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ERCC1. Each is linked with SH3PXD2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3PXD2A-to-partner and partner-to-SH3PXD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SH3PXD2A-low versus SH3PXD2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2A→partner) and Y-score (partner→SH3PXD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.146	+2.824	.003	.034	3	2
UCEC	EGFR_pY1068 →	-0.217	-1.347	.002	.006	3	2
UCEC	ERCC1 →	-0.101	-1.662	.042	.010	3	2
UCEC	ERK2 →	+0.117	+1.678	.034	.019	3	2
UCEC	MSH2 →	-0.191	-0.999	.003	.042	3	2
UCEC	Rictor_pT1135 →	-0.085	-1.847	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by SH3PXD2A expression — COAD

Explore this box plot interactively →