SH3PXD2A

Across TCGA cell cohorts, SH3PXD2A mutation is significantly associated with the RNA expression of many other genes, with 198 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3PXD2A-associated genes across cancer lineages are TEX53, KRTAP2-1, and TFDP3. Each is linked with SH3PXD2A in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3PXD2A-to-partner and partner-to-SH3PXD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX53 grouped by SH3PXD2A-low versus SH3PXD2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3PXD2A→partner) and Y-score (partner→SH3PXD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX53 →	+0.066	+2.777	.001	.004	3	3
LUNG_NSCLC_LUAD	KRTAP2-1 →	+0.138	+3.866	<.001	.006	3	2
LARGE_INTESTINE	TFDP3 →	+0.021	+2.518	<.001	.006	3	2
BLOOD_Leukemia	F11 →	+0.059	+3.078	<.001	<.001	3	2
STOMACH	CLEC3A →	+1.144	+3.688	.004	.007	3	2
BLOOD_Leukemia	FBXO15 →	+0.510	+3.199	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

TEX53 by SH3PXD2A expression — LARGE_INTESTINE

Explore this box plot interactively →