SH3PXD2A-AS1

Across TCGA pan-cancer cohorts, SH3PXD2A-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SH3PXD2A-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SH3PXD2A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH3PXD2A-AS1 expression acts as an unfavorable survival marker, although some lineages such as SARC and COAD show a favorable association.

UVM, LUAD, and PAAD are the cancer types where SH3PXD2A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.295	0.702	<.001	95	view →
LUAD	OS	Median	All	0.714	0.848	.001	81	view →
PAAD	DFS	Quartile	All	0.148	0.397	.002	49	view →
READ	DFS	Median	II,III,IV	0.566	0.792	.013	27	view →
KIRP	DFS	Quartile	All	0.478	0.900	.003	20	view →
MESO	OS	Median	All	0.288	0.679	.007	17	view →
SARC	OS	Quartile	All	0.822	0.601	<.001	11	view →
COAD	OS	Median	IV	0.845	0.304	.003	9	view →
SKCM	DFS	Tertile	All	0.655	0.834	.008	8	view →
KIRC	DFS	Tertile	All	0.870	0.727	.012	8	view →
STAD	OS	Median	All	0.643	0.486	.032	6	view →
LAML	DFS	Tertile	All	0.760	0.484	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SH3PXD2A-AS1–UVM (DFS)

Open the UVM breakdown →