SH3PXD2A-AS1

Across TCGA pan-cancer cohorts, SH3PXD2A-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SH3PXD2A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SH3PXD2A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SH3PXD2A-AS1 is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where SH3PXD2A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3PXD2A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+2.017	<.001	11	view →
KIRC	Female	All	+0.265	<.001	11	view →
THCA	Female	II,III,IV	+0.224	<.001	9	view →
LUSC	Male	All	+2.004	<.001	7	view →
LIHC	All	All	+0.076	<.001	6	view →
LUAD	All	All	+0.402	.001	4	view →
KIRP	Female	All	−0.070	.037	3	view →
PAAD	All	All	+2.850	.043	2	view →
READ	Female	All	+2.554	<.001	2	view →
CHOL	All	All	+0.360	.004	2	view →
BRCA	All	III,IV	−0.210	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SH3PXD2A-AS1–COAD

Open the COAD breakdown →