SH3KBP1

Across TCGA patient cohorts, SH3KBP1 mutation is significantly associated with the RNA expression of many other genes, with 4,785 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3KBP1-associated genes across cancer lineages are BNIP3P6, CRYBB2P1, and RTCB. Each is linked with SH3KBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3KBP1-to-partner and partner-to-SH3KBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P6 grouped by SH3KBP1-low versus SH3KBP1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3KBP1→partner) and Y-score (partner→SH3KBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	BNIP3P6 →	+0.471	+5.925	<.001	.002	3	2
UCEC	CRYBB2P1 →	+0.277	+1.715	.008	.002	3	2
UCEC	RTCB →	+0.432	+2.717	<.001	<.001	3	2
UCEC	JOSD1 →	+0.424	+1.963	<.001	<.001	3	2
UCEC	PACSIN2 →	+0.521	+1.624	<.001	<.001	3	2
UCEC	TOM1 →	+0.261	+1.427	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,785 associations by consensus.

BNIP3P6 by SH3KBP1 expression — READ

Explore this box plot interactively →