SH3GLB1

Across TCGA pan-cancer cohorts, SH3GLB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SH3GLB1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SH3GLB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH3GLB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where SH3GLB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.439	0.871	.008	13	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
UCEC	DFS	Quartile	All	1.000	0.793	.003	8	view →
HNSC	DFS	Quartile	IV	0.880	0.571	.028	5	view →
LUAD	OS	Quartile	II,III,IV	0.304	0.822	.020	2	view →
CCRCC	OS	Median	All	0.682	0.925	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SH3GLB1–LSCC (DFS)

Open the LSCC breakdown →