SH3GLB1

Across TCGA pan-cancer cohorts, SH3GLB1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SH3GLB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SH3GLB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SH3GLB1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where SH3GLB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3GLB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.674	<.001	12	view →
COAD	All	All	−0.457	<.001	9	view →
KICH	Female	All	−1.367	<.001	8	view →
LIHC	All	II,III,IV	+0.641	<.001	8	view →
BRCA	All	III,IV	−0.607	<.001	6	view →
LUSC	All	II,III,IV	−0.546	<.001	6	view →
LUAD	Female	All	−0.246	.002	4	view →
CHOL	Female	All	+1.960	<.001	3	view →
UCEC	All	All	−0.579	<.001	2	view →
READ	All	All	−0.537	.017	2	view →
PRAD	All	All	−0.383	<.001	2	view →
HNSC	Female	III,IV	+0.535	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SH3GLB1–KIRC

Open the KIRC breakdown →