SH3GLB1

Across TCGA patient cohorts, SH3GLB1 mutation is significantly associated with the RNA expression of many other genes, with 3,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GLB1-associated genes across cancer lineages are OR5M13P, CDH12P2, and IGHV1-69D. Each is linked with SH3GLB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GLB1-to-partner and partner-to-SH3GLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M13P grouped by SH3GLB1-low versus SH3GLB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GLB1→partner) and Y-score (partner→SH3GLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5M13P →	+0.074	+8.055	<.001	.007	3	2
UCEC	CDH12P2 →	+0.020	+3.777	<.001	.007	3	2
UCEC	IGHV1-69D →	+1.222	+2.906	.008	.001	3	1
UCEC	LINC00294 →	+0.401	+2.946	.002	<.001	3	1
UCEC	ARRDC3-AS1 →	+0.224	+2.223	.002	<.001	3	1
UCEC	RASSF1-AS1 →	+0.570	+4.043	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,709 associations by consensus.

OR5M13P by SH3GLB1 expression — BRCA

Explore this box plot interactively →