SH3GLB1

Across TCGA cell cohorts, SH3GLB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,269 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3GLB1-associated GO terms across cancer lineages are Regulation of plasma membrane organization, Regulation of stress-activated protein kinase signaling cascade, and Regulation of post-translational protein modification. Each is linked with SH3GLB1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SH3GLB1-to-partner and partner-to-SH3GLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasma membrane organization grouped by SH3GLB1-low versus SH3GLB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GLB1→partner) and Y-score (partner→SH3GLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of plasma membrane organization →	+0.195	+1.574	<.001	<.001	3	15
LIVER	Regulation of stress-activated protein kinase signaling cascade →	+0.131	+0.747	.005	.009	3	13
OVARY	Regulation of post-translational protein modification →	+0.057	+0.728	<.001	<.001	3	13
BREAST	Regulation of protein localization to mitochondrion →	+0.147	+0.970	<.001	<.001	3	13
BONE	Zinc ion import into Golgi lumen →	+0.110	+1.169	.002	.001	3	13
OVARY	Regulation of protein modification by small protein conjugation or removal →	+0.069	+0.854	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,269 associations by consensus.

Regulation of plasma membrane organization by SH3GLB1 expression — BONE

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