SH3GL3

Across TCGA patient cohorts, SH3GL3 mutation is significantly associated with the RNA expression of many other genes, with 2,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GL3-associated genes across cancer lineages are EME1, CCNF, and SKA3. Each is linked with SH3GL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3GL3-to-partner and partner-to-SH3GL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by SH3GL3-low versus SH3GL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL3→partner) and Y-score (partner→SH3GL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.533	+1.903	<.001	<.001	3	3
UCEC	CCNF →	+0.447	+1.425	.007	.006	3	3
UCEC	SKA3 →	+0.599	+3.043	<.001	<.001	3	3
UCEC	RRM2 →	+0.948	+2.169	<.001	<.001	3	3
UCEC	RAD51 →	+0.792	+2.868	<.001	<.001	3	3
UCEC	POLQ →	+0.391	+1.966	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,126 associations by consensus.

EME1 by SH3GL3 expression — UCEC

Explore this box plot interactively →