SH3GL2

Across TCGA patient cohorts, SH3GL2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,091 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SH3GL2-associated genes across cancer lineages are ADGRB3, UNC5D, and ST6GALNAC3. Each is linked with SH3GL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SH3GL2-to-partner and partner-to-SH3GL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3GL2 versus ADGRB3 in GBM, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL2→partner) and Y-score (partner→SH3GL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADGRB3 →	+1.452	+0.789	<.001	<.001	3	4
CCRCC	UNC5D →	+1.137	+0.643	<.001	<.001	3	4
GBM	ST6GALNAC3 →	+0.946	+0.652	<.001	<.001	3	4
UCEC	TCEAL2 →	+0.943	+0.560	<.001	<.001	3	4
GBM	ITPRIPL2 →	-0.509	-0.953	<.001	<.001	3	4
UCEC	CBLN1 →	+0.691	+0.473	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,091 associations by consensus.

SH3GL2 vs ADGRB3 — GBM

Explore this scatter interactively →