Across TCGA patient cohorts, SH3D21 protein abundance is significantly associated with the RNA expression of many other genes, with 1,537 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SH3D21-associated genes across cancer lineages are TBX18, RNASEL, and SERPINE2. Each is linked with SH3D21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3D21-to-partner and partner-to-SH3D21 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D21→partner) and Y-score (partner→SH3D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TBX18 →	+2.100	+0.870	.005	<.001	3	1
BRCA	RNASEL →	+0.682	+0.884	.008	.006	2	2
PDAC	SERPINE2 →	-1.077	-0.807	.005	.004	3	1
PDAC	DNAJB2 →	+0.703	+1.100	.002	.001	3	1
PDAC	TRIM29 →	+2.128	+0.870	.001	<.001	3	1
PDAC	TMEM50B →	+0.601	+0.870	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,537 associations by consensus.

Exploration

SH3D21 survival (RNA) · tumor vs normal (RNA) · all SH3D21 data types