SH3D19

Across TCGA patient cohorts, SH3D19 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3D19-associated genes across cancer lineages are eIF4E, PRDX1, and S6_pS240_S244. Each is linked with SH3D19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3D19-to-partner and partner-to-SH3D19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SH3D19-low versus SH3D19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D19→partner) and Y-score (partner→SH3D19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.200	+2.321	.003	<.001	3	2
UCEC	PRDX1 →	+0.155	+1.502	.020	.027	3	2
UCEC	S6_pS240_S244 →	+0.275	+2.115	.036	.017	3	2
UCEC	STAT3_pY705 →	-0.423	-1.864	<.001	.002	3	2
UCEC	ASNS →	+0.439	+1.847	<.001	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.508	+1.341	.008	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

eIF4E by SH3D19 expression — UCEC

Explore this box plot interactively →