SH3D19

Across TCGA cell cohorts, SH3D19 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,793 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3D19-associated GO terms across cancer lineages are ERBB signaling pathway, Cellular response to transforming growth factor beta stimulus, and Negative regulation of actin filament depolymerization. Each is linked with SH3D19 in more than 10 cancer types. Because this analysis shows association rather than direction, both SH3D19-to-partner and partner-to-SH3D19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERBB signaling pathway grouped by SH3D19-low versus SH3D19-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D19→partner) and Y-score (partner→SH3D19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ERBB signaling pathway →	+0.070	+1.676	.006	.007	3	11
BONE	Cellular response to transforming growth factor beta stimulus →	+0.063	+1.839	<.001	<.001	3	9
BONE	Negative regulation of actin filament depolymerization →	+0.206	+1.832	<.001	<.001	3	9
BONE	Regulation of membrane protein ectodomain proteolysis →	+0.143	+1.796	<.001	.004	3	9
BONE	Actin filament capping →	+0.227	+1.985	<.001	<.001	3	9
BONE	Protein localization to plasma membrane →	+0.086	+2.456	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,793 associations by consensus.

ERBB signaling pathway by SH3D19 expression — BONE

Explore this box plot interactively →