SH3D19

Across TCGA cell cohorts, SH3D19 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3D19-associated genes across cancer lineages are ZPBP2, MRAP, and TSPY3. Each is linked with SH3D19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3D19-to-partner and partner-to-SH3D19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZPBP2 grouped by SH3D19-low versus SH3D19-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D19→partner) and Y-score (partner→SH3D19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZPBP2 →	+0.610	+3.777	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TSPY3 →	+0.626	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	C1orf232 →	+0.084	+4.736	<.001	.009	3	1
OVARY	OR13C5 →	+0.014	+4.339	.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+5.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ZPBP2 by SH3D19 expression — BLOOD_Leukemia

Explore this box plot interactively →