SH3BP5L

Across TCGA patient cohorts, SH3BP5L mutation is significantly associated with the RNA expression of many other genes, with 865 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP5L-associated genes across cancer lineages are RN7SL237P, RNU4-71P, and RNA5SP22. Each is linked with SH3BP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP5L-to-partner and partner-to-SH3BP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL237P grouped by SH3BP5L-low versus SH3BP5L-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5L→partner) and Y-score (partner→SH3BP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL237P →	+0.244	+5.418	<.001	.005	3	2
HNSC	RNU4-71P →	+0.218	+7.954	<.001	.008	3	2
STAD	RNA5SP22 →	+0.259	+3.646	.008	.009	3	2
STAD	RN7SL369P →	+0.195	+4.139	.005	.004	3	2
STAD	RN7SKP43 →	+0.363	+3.879	<.001	.006	3	2
STAD	RNU4ATAC14P →	+0.681	+3.736	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 865 associations by consensus.

RN7SL237P by SH3BP5L expression — CESC

Explore this box plot interactively →