SH3BP4

Across TCGA cell cohorts, SH3BP4 mutation is significantly associated with the RNA expression of many other genes, with 373 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BP4-associated genes across cancer lineages are OR2AK2, OR2L8, and VIPR2. Each is linked with SH3BP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP4-to-partner and partner-to-SH3BP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AK2 grouped by SH3BP4-low versus SH3BP4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP4→partner) and Y-score (partner→SH3BP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2AK2 →	+0.078	+4.029	<.001	.009	3	2
OVARY	OR2L8 →	+0.030	+4.450	<.001	.004	3	2
BLOOD_Leukemia	VIPR2 →	+1.426	+3.507	<.001	.003	3	2
BLOOD_Leukemia	ERGIC1 →	+1.115	+2.489	.004	.007	3	2
BLOOD_Leukemia	SMIM14 →	+1.390	+2.608	.002	.005	3	2
BLOOD_Leukemia	FBXO33 →	+0.521	+2.503	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 373 associations by consensus.

OR2AK2 by SH3BP4 expression — OVARY

Explore this box plot interactively →