SH3BP1

Across TCGA pan-cancer cohorts, SH3BP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SH3BP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SH3BP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3BP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where SH3BP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.487	0.219	.002	28	view →
HNSC	OS	Tertile	III,IV	1.000	0.277	.008	23	view →
LUAD	DFS	Quartile	All	0.891	0.495	<.001	17	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SH3BP1–PDAC (DFS)

Open the PDAC breakdown →