SH3BGRL3

Across TCGA pan-cancer cohorts, SH3BGRL3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH3BGRL3 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SH3BGRL3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SH3BGRL3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

GBM, CCRCC, and PDAC are the cancer types where SH3BGRL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.362	0.685	<.001	17	view →
CCRCC	OS	Tertile	III,IV	0.635	0.963	.003	17	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LSCC	DFS	Quartile	II,III,IV	0.499	0.860	.039	4	view →
LUAD	DFS	Median	All	0.829	0.526	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH3BGRL3–GBM (OS)

Open the GBM breakdown →