SH3BGRL3

Across TCGA pan-cancer cohorts, SH3BGRL3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SH3BGRL3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SH3BGRL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SH3BGRL3 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where SH3BGRL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3BGRL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.228	<.001	12	view →
THCA	Male	III,IV	+1.392	<.001	10	view →
LIHC	Female	II,III,IV	+1.392	<.001	9	view →
KIRP	Male	III,IV	+1.077	<.001	9	view →
HNSC	All	All	+0.616	<.001	9	view →
KICH	Female	II,III,IV	−1.325	<.001	7	view →
UCEC	All	II,III,IV	+0.779	<.001	6	view →
BRCA	All	III,IV	+0.681	<.001	6	view →
STAD	All	All	+0.701	<.001	5	view →
CHOL	All	All	+2.313	<.001	3	view →
PAAD	Female	All	+0.484	.011	2	view →
COAD	Female	All	−0.349	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SH3BGRL3–KIRC

Open the KIRC breakdown →