SH3BGRL3

Across TCGA patient cohorts, SH3BGRL3 protein abundance is significantly associated with the RNA expression of many other genes, with 21,276 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH3BGRL3-associated genes across cancer lineages are CD244, SPN, and TIFAB. Each is linked with SH3BGRL3 in more than 8 cancer types. Because this analysis shows association rather than direction, both SH3BGRL3-to-partner and partner-to-SH3BGRL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3BGRL3 versus CD244 in LSCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL3→partner) and Y-score (partner→SH3BGRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD244 →	+0.829	+0.395	<.001	<.001	3	9
OV	SPN →	+1.029	+0.449	<.001	<.001	3	9
CCRCC	TIFAB →	+0.701	+0.289	<.001	<.001	3	9
CCRCC	IL21R →	+1.128	+0.314	<.001	<.001	3	8
OV	LPXN →	+0.694	+0.308	<.001	.004	3	8
OV	SELPLG →	+1.363	+0.503	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,276 associations by consensus.

SH3BGRL3 vs CD244 — LSCC

Explore this scatter interactively →