SH3BGRL3

Across TCGA patient cohorts, SH3BGRL3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BGRL3-associated genes across cancer lineages are LINC02281, RNA5SP386, and MIR4290. Each is linked with SH3BGRL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BGRL3-to-partner and partner-to-SH3BGRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02281 grouped by SH3BGRL3-low versus SH3BGRL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL3→partner) and Y-score (partner→SH3BGRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02281 →	+0.239	+7.741	<.001	.009	3	1
UCEC	RNA5SP386 →	+0.561	+3.520	<.001	.006	3	1
UCEC	MIR4290 →	+0.268	+5.414	<.001	.001	3	1
UCEC	MIR4672 →	+0.607	+3.041	<.001	.008	3	1
UCEC	RN7SL140P →	+0.142	+4.260	.004	.007	3	1
UCEC	ATP6V1E1P2 →	+0.402	+3.492	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

LINC02281 by SH3BGRL3 expression — COAD

Explore this box plot interactively →