SH3BGRL3

Across TCGA cell cohorts, SH3BGRL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,318 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3BGRL3-associated GO terms across cancer lineages are Actin filament organization, Integrin-mediated signaling pathway, and Regulation of plasminogen activation. Each is linked with SH3BGRL3 in more than 15 cancer types. Because this analysis shows association rather than direction, both SH3BGRL3-to-partner and partner-to-SH3BGRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament organization grouped by SH3BGRL3-low versus SH3BGRL3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL3→partner) and Y-score (partner→SH3BGRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament organization →	+0.124	+1.240	<.001	<.001	3	16
BONE	Integrin-mediated signaling pathway →	+0.234	+1.092	<.001	<.001	3	16
LIVER	Regulation of plasminogen activation →	+0.322	+3.022	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of collagen metabolic process →	+0.247	+2.199	<.001	<.001	3	14
BONE	Cell-substrate adhesion →	+0.134	+1.094	<.001	<.001	3	14
BONE	Dentinogenesis →	+1.591	+1.234	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,318 associations by consensus.

Actin filament organization by SH3BGRL3 expression — BONE

Explore this box plot interactively →