SH3BGRL

Across TCGA pan-cancer cohorts, SH3BGRL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SH3BGRL data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SH3BGRL mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SH3BGRL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where SH3BGRL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	1.000	0.474	<.001	72	view →
PDAC	OS	Tertile	All	0.567	0.261	.006	34	view →
GBM	OS	Tertile	All	0.369	0.669	<.001	29	view →
LSCC	DFS	Median	II,III,IV	0.507	0.864	.002	27	view →
LUAD	OS	Quartile	All	0.827	0.509	.037	4	view →
UCEC	OS	Tertile	II,III,IV	0.625	1.000	.032	4	view →
HNSC	OS	Tertile	II,III,IV	0.941	1.000	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SH3BGRL–CCRCC (OS)

Open the CCRCC breakdown →