SH3BGRL

Across TCGA pan-cancer cohorts, SH3BGRL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SH3BGRL’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SH3BGRL RNA is repressed in tumor relative to normal tissue. In most cancer types SH3BGRL is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where SH3BGRL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3BGRL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.400	<.001	10	view →
COAD	Female	All	−1.131	<.001	10	view →
LUAD	Female	III,IV	−1.228	<.001	9	view →
LUSC	Male	III,IV	−2.580	<.001	8	view →
THCA	Male	All	−0.435	<.001	8	view →
UCEC	All	III,IV	−2.135	<.001	6	view →
BRCA	All	III,IV	+1.365	<.001	6	view →
CHOL	All	All	+1.674	<.001	5	view →
STAD	All	All	−0.757	.005	3	view →
READ	All	All	−1.078	.022	2	view →
PRAD	All	All	−0.731	<.001	2	view →
PAAD	Female	All	−0.620	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SH3BGRL–BLCA

Open the BLCA breakdown →