SH3BGRL

Across TCGA patient cohorts, SH3BGRL protein abundance is significantly associated with the RNA expression of many other genes, with 19,520 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH3BGRL-associated genes across cancer lineages are ATP8B4, LMOD1, and NAP1L3. Each is linked with SH3BGRL in more than 8 cancer types. Because this analysis shows association rather than direction, both SH3BGRL-to-partner and partner-to-SH3BGRL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3BGRL versus ATP8B4 in LSCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL→partner) and Y-score (partner→SH3BGRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATP8B4 →	+0.799	+0.545	<.001	<.001	3	9
UCEC	LMOD1 →	+1.902	+0.608	<.001	<.001	3	9
UCEC	NAP1L3 →	+0.962	+0.411	<.001	<.001	3	9
UCEC	GINS1 →	-0.783	-0.421	.001	<.001	3	8
UCEC	PLCL1 →	+0.896	+0.522	<.001	<.001	3	8
UCEC	CNRIP1 →	+0.884	+0.493	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,520 associations by consensus.

SH3BGRL vs ATP8B4 — LSCC

Explore this scatter interactively →