SH3BGRL

Across TCGA patient cohorts, SH3BGRL mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BGRL-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and MEK1. Each is linked with SH3BGRL in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BGRL-to-partner and partner-to-SH3BGRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SH3BGRL-low versus SH3BGRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL→partner) and Y-score (partner→SH3BGRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.212	-3.321	.005	.009	3	1
UCEC	Ku80 →	+0.248	+2.713	.020	.003	3	1
UCEC	MEK1 →	+0.349	+2.999	.034	.035	3	1
UCEC	Notch1 →	+0.129	+2.183	.041	.033	3	1
UCEC	Akt_pT308 →	+0.572	+2.000	.044	.032	3	1
UCEC	STAT3_pY705 →	-0.395	-2.000	<.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by SH3BGRL expression — UCEC

Explore this box plot interactively →