SH3BGRL

Across TCGA cell cohorts, SH3BGRL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,093 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SH3BGRL-associated GO terms across cancer lineages are Regulation of L-glutamate import across plasma membrane, Aminoacyl-tRNA metabolism involved in translational fidelity, and Endoplasmic reticulum mannose trimming. Each is linked with SH3BGRL in more than 10 cancer types. Because this analysis shows association rather than direction, both SH3BGRL-to-partner and partner-to-SH3BGRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of L-glutamate import across plasma membrane grouped by SH3BGRL-low versus SH3BGRL-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL→partner) and Y-score (partner→SH3BGRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of L-glutamate import across plasma membrane →	+0.156	+1.094	<.001	.005	2	11
OESOPHAGUS	Aminoacyl-tRNA metabolism involved in translational fidelity →	-0.085	-2.826	.002	<.001	3	7
SOFT_TISSUE	Endoplasmic reticulum mannose trimming →	+0.103	+1.540	<.001	.003	2	8
LUNG_NSCLC_LUAD	Regulation of stress-activated MAPK cascade →	+0.065	+1.101	<.001	.001	3	7
CNS	Enzyme-directed rRNA pseudouridine synthesis →	-0.056	-1.097	.005	.002	3	7
SOFT_TISSUE	Positive regulation of translational initiation →	+0.078	+1.483	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,093 associations by consensus.

Regulation of L-glutamate import across plasma membrane by SH3BGRL expression — SOFT_TISSUE

Explore this box plot interactively →