Across TCGA cell cohorts, SH3BGR mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SH3BGR-associated genes across cancer lineages are SCN10A, OR6M1, and SMR3A. Each is linked with SH3BGR in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BGR-to-partner and partner-to-SH3BGR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGR→partner) and Y-score (partner→SH3BGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCN10A →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.075	+5.228	<.001	.005	3	1
CNS	SMR3A →	+0.039	+4.754	<.001	.005	3	1
CNS	NEUROD4 →	+0.617	+4.832	<.001	.002	3	1
CNS	PTH2 →	+0.090	+4.321	<.001	.009	3	1
CNS	UCMA →	+0.207	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

SH3BGR survival (RNA) · tumor vs normal (RNA) · all SH3BGR data types