SH2D6

Across TCGA patient cohorts, SH2D6 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,157 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SH2D6-associated GO terms across cancer lineages are Establishment of protein localization to membrane, Protein localization to mitochondrion, and Protein targeting to mitochondrion. Each is linked with SH2D6 in more than 20 cancer types. Because this analysis shows association rather than direction, both SH2D6-to-partner and partner-to-SH2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to membrane grouped by SH2D6-low versus SH2D6-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D6→partner) and Y-score (partner→SH2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Establishment of protein localization to membrane →	+0.082	+0.319	<.001	<.001	3	21
STAD	Protein localization to mitochondrion →	+0.083	+0.315	<.001	<.001	3	20
STAD	Protein targeting to mitochondrion →	+0.081	+0.342	<.001	<.001	3	20
STAD	Peptidyl-lysine modification →	+0.046	+0.253	<.001	<.001	3	20
KIRC	Methylation →	+0.043	+0.214	<.001	<.001	3	20
STAD	Regulation of microtubule-based process →	+0.038	+0.268	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,157 associations by consensus.

Establishment of protein localization to membrane by SH2D6 expression — STAD

Explore this box plot interactively →