SH2D6

Across TCGA pan-cancer cohorts, SH2D6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SH2D6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SH2D6 RNA is repressed in tumor relative to normal tissue. In most cancer types SH2D6 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where SH2D6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH2D6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.408	<.001	12	view →
THCA	Male	III,IV	−2.422	<.001	11	view →
COAD	Male	IV	−2.094	<.001	11	view →
KIRP	All	III,IV	−0.630	<.001	10	view →
HNSC	All	All	+0.075	.004	7	view →
UCEC	All	All	+0.434	<.001	6	view →
BRCA	All	II,III,IV	+0.174	<.001	6	view →
KICH	Female	All	−0.521	<.001	4	view →
LIHC	All	All	+0.267	<.001	4	view →
READ	All	III,IV	−1.455	.017	2	view →
PRAD	All	All	−0.083	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SH2D6–KIRC

Open the KIRC breakdown →