SH2D6

Across TCGA patient cohorts, SH2D6 mutation is significantly associated with the RNA expression of many other genes, with 228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D6-associated genes across cancer lineages are RNU1-17P, MIR941-5, and NPBWR2. Each is linked with SH2D6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D6-to-partner and partner-to-SH2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by SH2D6-low versus SH2D6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D6→partner) and Y-score (partner→SH2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.462	+5.103	<.001	.008	3	2
CESC	MIR941-5 →	+0.666	+5.418	<.001	.005	3	2
CESC	NPBWR2 →	+0.043	+5.010	<.001	.009	3	1
CESC	OR1D2 →	+0.071	+5.969	<.001	.002	3	1
CESC	PABPC1L2A →	+0.057	+5.669	<.001	.003	3	1
CESC	RNA5SP432 →	+0.420	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 228 associations by consensus.

RNU1-17P by SH2D6 expression — CESC

Explore this box plot interactively →