SH2D6

Across TCGA patient cohorts, SH2D6 mutation is significantly associated with the total protein of many other genes, with 1 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D6-associated genes across cancer lineages are VEGFR2. Each is linked with SH2D6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D6-to-partner and partner-to-SH2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by SH2D6-low versus SH2D6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D6→partner) and Y-score (partner→SH2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.552	+2.820	.002	.036	1	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

VEGFR2 by SH2D6 expression — UCEC

Explore this box plot interactively →