SH2D6

Across TCGA cell cohorts, SH2D6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,936 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH2D6-associated GO terms across cancer lineages are Cilium movement involved in cell motility, Cilium movement, and Non-proteinogenic amino acid biosynthetic process. Each is linked with SH2D6 in more than 6 cancer types. Because this analysis shows association rather than direction, both SH2D6-to-partner and partner-to-SH2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement involved in cell motility grouped by SH2D6-low versus SH2D6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D6→partner) and Y-score (partner→SH2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.083	-0.192	.009	.006	3	7
LUNG_NSCLC_LUSC	Cilium movement →	-0.052	-0.296	.004	.008	3	7
URINARY_TRACT	Non-proteinogenic amino acid biosynthetic process →	+0.151	+0.267	.007	<.001	2	7
OVARY	Calcium-independent cell-matrix adhesion →	+0.146	+0.421	<.001	.001	3	6
OESOPHAGUS	Glycine metabolic process →	-0.144	-0.334	.007	.008	2	7
BLOOD_Leukemia	Nucleotide-excision repair →	+0.030	+0.262	.004	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,936 associations by consensus.

Cilium movement involved in cell motility by SH2D6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →