SH2D4B

Across TCGA patient cohorts, SH2D4B RNA expression is significantly associated with the go_rna of many other GO terms, with 7,143 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SH2D4B-associated GO terms across cancer lineages are TOR signaling, Myeloid cell apoptotic process, and Cellular senescence. Each is linked with SH2D4B in more than 23 cancer types. Because this analysis shows association rather than direction, both SH2D4B-to-partner and partner-to-SH2D4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOR signaling grouped by SH2D4B-low versus SH2D4B-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4B→partner) and Y-score (partner→SH2D4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TOR signaling →	+0.059	+0.142	<.001	<.001	3	24
STAD	Myeloid cell apoptotic process →	+0.048	+0.109	<.001	<.001	3	24
SCLC	Cellular senescence →	+0.099	+0.344	<.001	.007	2	24
STAD	Biological process involved in interaction with host →	+0.064	+0.156	<.001	<.001	3	23
STAD	Regulation of protein serine/threonine kinase activity →	+0.053	+0.146	<.001	<.001	3	23
STAD	Regulation of protein polymerization →	+0.060	+0.136	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,143 associations by consensus.

TOR signaling by SH2D4B expression — STAD

Explore this box plot interactively →